In children under 5 years of age, systemic reactions (e.g. fever, malaise, myalgia) may be more pronounced. Local Reactions: Erythema (redness), swelling, pain, ecchymosis, induration. Systemic Reactions: Fever, malaise, shivering, fatigue, headache, sweating, joint and muscular pain. These reactions usually disappear within 1-2 days without treatment. Rarely: Neuralgia, paresthesia, convulsions and transient thrombocytopenia Allergic reactions leading to shock in rare cases. Vasculitis with transient renal involvement, in very rare cases.